02 March 2009
By:Guifeng Jiang
Forensic laboratories face a daunting task to identify trace amounts of controlled substances in small samples of seized evidence. Unambiguous identification is required to meet the stiff challenge that is sure to be raised in the courtroom. Positive proof is especially difficult to establish if the controlled substance is hidden in a complex food matrix with a high content of sugars, fats, fatty acids, proteins and alkaloids.
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02 March 2009
By:Srinivasa Rao, Charanjit Saini, Chris Pohl
The new reversed-phase ProSwift 1 mm i.d. column is a divinylbenzene-based monolithic column for routine chromatography of proteins and other biomolecules. It is available in two different lengths.
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02 December 2008
By:C.E. Blythe, S. Aspey, L. Pereira, D. Milton
Benzodiazepines are psychoactive drugs primarily used for their tranquilizing and sedative effects. In clinical settings, the concentration of benzodiazepines in biological matrices is often monitored to determine the efficacy of therapeutic doses. Increasingly, for legal/criminal investigations, there is a requirement for robust and reliable separation methods for this class of drugs.
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02 December 2008
Dedicated therapy with low concentrated pharmaceuticals requires drug monitoring to avoid overdoses and maintain the effective concentration. Extraction of these drugs from blood samples using standard procedures such as SPE extraction are not easy and may need optimizing, depending on the drug, its protein binding and variation between patients.
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02 December 2008
By:Pingyi Zhang
In the last few decades, the novel functions of polysaccharides have provided a major impetus for increasing scientific attention. Among the most promising aspects are their immunomodulatory and antitumor effects, thickening agents and stabilizer effects.
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02 December 2008
By:Erin E. Chambers, Diane M. Diehl
A highly sensitive analytical method for the analysis of tamsulosin in human plasma has been developed for use in bioanalytical studies. The solid-phase extraction (SPE) and UPLC–MS–MS methodologies are described, as well as performance against validation parameters.
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02 December 2008
By:Silvia Marten
Catecholamines are important markers for the diagnosis and management of tumour diseases of the sympathoadrenal system. The major catecholamines are dopamine, norepinephrine and epinephrine. Urine tests have shown to be applicable to measure the level of catecholamines in the human body. Various separation methods have been used for the clean-up of catecholamines in biological fluids: solvent extraction, adsorption on alumina, ion-exchange and solid-phase extraction of a diphenylboronic acid-catecholamine complex.
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