What do you do when the method can't be reproduced?

Ion-pair chromatography can be your best friend or your worst enemy.

If the problem source cannot be found or if found, cannot be corrected, an adjustment in flow-rate is justified.

A very efficient way to start an isocratic method development project is to make the first run as a scouting gradient run.

Trade extra resolution for speed.

How to avoid an expensive shot in the dark.

How do I get the most out of my efforts?

Faster isn't always better.

Getting started on the right foot is important for efficient method development.